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Article

A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene.

Environmental and molecular mutagenesis - 1 Jan 2003

Wickliffe Jeffrey K, Ammenheuser Marinel M, Salazar James J, Abdel-Rahman Sherif Z, Hastings-Smith Darlene A, Postlethwait Edward M, Lloyd R Stephen, Ward Jonathan B

Abstract excerpt

The specific role that polymorphisms in xenobiotic metabolizing enzymes play in modulating sensitivity to 1,3-butadiene (BD) genotoxicity has been relatively unexplored. The enzyme microsomal epoxide hydrolase (mEH) is important in detoxifying the mutagenic epoxides of BD (butadiene monoepoxide [BDO], butadiene diepoxide [BDO(2)]). Polymorphisms in the human mEH gene appear to affect the function of the enzyme....

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PMID: 12929123
DOI: 10.1002/em.10181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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