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Article

Gene function prediction from congruent synthetic lethal interactions in yeast.

Molecular systems biology - 1 Jan 2005

Ye Ping, Peyser Brian D, Pan Xuewen, Boeke Jef D, Spencer Forrest A, Bader Joel S

Abstract excerpt

We predicted gene function using synthetic lethal genetic interactions between null alleles in Saccharomyces cerevisiae. Phenotypic and protein interaction data indicate that synthetic lethal gene pairs function in parallel or compensating pathways. Congruent gene pairs, defined as sharing synthetic lethal partners, are in single pathway branches. We predicted benomyl sensitivity and nuclear migration defects...

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Identifiers

PMID: 16729061
DOI: 10.1038/msb4100034
PMCID: PMC1681444

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