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Article

Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals.

Journal of clinical laboratory analysis - 1 Apr 2022

Jafari Roshan Samaneh, Mansoori Yaser, Hosseini Seyed Reza, Sabour Davood, Daraei Abdolreza

Abstract excerpt

BACKGROUND: Loci controlling DNA double-strand breaks (DSBs) repair play an important role in defending against the harmful health effects of benzene, toluene, ethylbenzene, and xylene (BTEX), but their gene variants may alter their repair capacity. The aim of the current study was to determine the relationship of functional polymorphisms ATM-rs228589 A>T, WRN-rs1800392 G>T and H2AX-rs7759 A>G in DBS repair loci...

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Identifiers

PMID: 35235704
DOI: 10.1002/jcla.24321
PMCID: PMC8993635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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