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Article

Biochemical analysis of the ligand for the neu oncogenic receptor.

Biochemistry - 9 Apr 1991

Yarden Y, Peles E

Abstract excerpt

The neu protooncogene (also called HER2 and c-erbB2) encodes a cell-surface tyrosine kinase structurally related to the receptor for the epidermal growth factor (EGF). We have previously reported that a candidate ligand for the neu receptor is secreted by ras-transformed fibroblasts. Biochemical analyses of the neu stimulatory activity indicate that the ligand is a 35-kDa glycoprotein that is heat stable but...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1672825
DOI: 10.1021/bi00228a027

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Biochemical analysis of the ligand for the neu oncogenic receptor.PMID 1672825Read ↗

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.Semantic proximity Read ↗

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Differential processing and turnover of the oncogenically activated neu/erb B2 gene product and its normal cellular counterpart.Semantic proximity Read ↗

Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.Semantic proximity Read ↗

Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B.Semantic proximity Read ↗

Overexpression of RasN17 fails to neutralize endogenous Ras in MCF7 breast cancer cells.Semantic proximity Read ↗

Diagnostic utility of oncogenes and their products in human cancer.Semantic proximity Read ↗

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