Article
Biochemical analysis of the ligand for the neu oncogenic receptor.
Biochemistry - 9 Apr 1991
Yarden Y, Peles E
Abstract excerpt
The neu protooncogene (also called HER2 and c-erbB2) encodes a cell-surface tyrosine kinase structurally related to the receptor for the epidermal growth factor (EGF). We have previously reported that a candidate ligand for the neu receptor is secreted by ras-transformed fibroblasts. Biochemical analyses of the neu stimulatory activity indicate that the ligand is a 35-kDa glycoprotein that is heat stable but...
Topics
- Chromatography, Affinity
- Chromatography, Gel
- Enzyme Stability
- ErbB Receptors
- Glycoproteins
- Heparin
- Humans
- Ligands
- Mutation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Receptor, ErbB-2