Article
Dendritic cells fused with mastocytoma cells elicit therapeutic antitumor immunity.
International journal of cancer - 13 Apr 1998
Lespagnard L, Mettens P, Verheyden A M, Tasiaux N, Thielemans K, van Meirvenne S, Geldhof A, De Baetselier P, Urbain J, Leo O, Moser M
Abstract excerpt
Characterization of the spontaneous immune response that frequently occurs in tumor-bearing animals, as well as immunization using dendritic cells pulsed with tumor antigens, suggests that a limiting factor of the tumor-specific immune response may be a defect in the co-stimulatory signal that is...
Topics
- Animals
- Bone Marrow Cells
- Cell Fusion
- Dendritic Cells
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
- Immunotherapy, Adoptive
- Mast-Cell Sarcoma
- Mice
- Mice, Inbred CBA
- Mice, Inbred DBA
- Phenotype
- RNA, Messenger
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha