Article
Dendritic cells fused with mastocytoma cells elicit therapeutic antitumor immunity.
International journal of cancer - 13 Apr 1998
Lespagnard L, Mettens P, Verheyden A M, Tasiaux N, Thielemans K, van Meirvenne S, Geldhof A, De Baetselier P, Urbain J, Leo O, Moser M
Abstract excerpt
Characterization of the spontaneous immune response that frequently occurs in tumor-bearing animals, as well as immunization using dendritic cells pulsed with tumor antigens, suggests that a limiting factor of the tumor-specific immune response may be a defect in the co-stimulatory signal that is required for optimal activation of T cells. In this work, we describe a new approach to improve the antigen-presenting...
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