Article
Phenotypic and functional characterization of tumor infiltrating lymphocytes in mycosis fungoides: continuous growth of CD4+ CD45R+ T-cell clones with suppressor-inducer activity.
The Journal of investigative dermatology - 1 Mar 1990
Reinhold U, Pawelec G, Fratila A, Leippold S, Bauer R, Kreysel H W
Abstract excerpt
Tumor-infiltrating lymphocytes (TIL) were obtained by mechanical release from a solitary rapidly grown tumor of a patient with mycosis fungoides. The preparations separated by density gradient centrifugation contained a major portion of CD3+ CD8+ WT31+ CD5- large T-cell blasts and a minor portion of non-blastic TIL predominantly of the CD3+ CD4+ phenotype. Using cDNA-probes for the constant region of the T-cell...
Topics
- Antigens, CD
- Antigens, Differentiation
- Antigens, Neoplasm
- Antigens, Surface
- CD4 Antigens
- Cell Division
- DNA
- Female
- Humans
- Leukocyte Common Antigens
- Lymphocytes