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Article

Uncoupling T‐cell expansion from effector differentiation in cell‐based immunotherapy

13 Dec 2013

Abstract excerpt

Adoptive cellular immunotherapy (ACT) is a potentially curative therapy for patients with advanced cancer. Eradication of tumor in mouse models and humans correlates with both a high dose of adoptively transferred cells and cells with a minimally differentiated phenotype that maintain replicative capacity and multipotency. We speculate that response to ACT not only requires transfer of cells with immediate...

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PMID: 24329803
DOI: 10.1111/imr.12135

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