Article
Expression of the E2A-PBX1 fusion transcripts in t(1;19)(q23;p13) and der(19)t(1;19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes.
Leukemia - 1 May 1995
Devaraj P E, Foroni L, Janossy G, Hoffbrand A V, Secker-Walker L M
Abstract excerpt
The chromosomal translocation t(1;19)(q23;p13) and its variant form der(19)t(1;19) found in 3-5% of acute lymphoblastic leukemia (ALL) results in the expression of the E2A-PBX1 fusion transcript. Although strongly associated with a pre-B immunophenotype, we report the occurrence of t(1;19) in bon...
Topics
- Adolescent
- Adult
- Aged
- B-Lymphocytes
- Base Sequence
- Blotting, Southern
- Burkitt Lymphoma
- Child
- Child, Preschool
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 19
- Female
- Gene Expression
- Gene Rearrangement
- Genetic Variation
- Homeodomain Proteins
- Humans
- Immunophenotyping