Article
Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia.
Blood - 15 Sept 1992
Izraeli S, Kovar H, Gadner H, Lion T
Abstract excerpt
The t(1;19)(q23;p13) is the most common recurring chromosomal translocation in childhood acute lymphoblastic leukemia (ALL) and has been associated with adverse prognosis. It involves the rearrangement of two genes, PBX1 and E2A, resulting in the production of transforming chimeric DNA-binding pr...
Topics
- Adolescent
- Amino Acid Sequence
- Base Sequence
- Child
- Child, Preschool
- Female
- Gene Amplification
- Gene Rearrangement
- Genetic Variation
- Humans
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- RNA, Messenger
- Recombinant Fusion Proteins
- Sequence Homology, Nucleic Acid
- Transcription, Genetic