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Article

The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias

15 Feb 1991

Abstract excerpt

The t(1;19)(q23;p13) chromosomal translocation is observed cytogenetically in 25% of children with pre-B-cell acute lymphoblastic leukemia (ALL) and is associated with an adverse treatment outcome. The t(1;19) juxtaposes the E2A gene from chromosome 19 with the PBX1 gene on chromosome 1, leading to the production of fusion transcripts and resultant chimeric proteins that contain the transcriptional-activating...

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Identifiers

PMID: 1671560
DOI: 10.1182/blood.v77.4.687.687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemiasPMID 1671560Read ↗

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Identification of a novel fusion gene in a pre‐B acute lymphoblastic leukemia with t(1;19)(q23;p13)Semantic proximity Read ↗

Molecular investigation of 19p13 in standard and variant translocations: the E12 probe recognizes the 19p13 breakpoint in cases with t(1;19) and acute leukemia other than pre-B immunophenotype.Semantic proximity Read ↗

Site-specific translocation and evidence of postnatal origin of the t(1;19) <i>E2A-PBX1</i> fusion in childhood acute lymphoblastic leukemiaSemantic proximity Read ↗

Predictability of the t(1;19)(q23;p13) from surface antigen phenotype: implications for screening cases of childhood acute lymphoblastic leukemia for molecular analysis: a Pediatric Oncology Group studySemantic proximity Read ↗

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E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice.Semantic proximity Read ↗

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Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia.Semantic proximity Read ↗

Molecular cytogenetic characterization of <i>TCF3 (E2A)</i>/19p13.3 rearrangements in B‐cell precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

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