Article
N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.
Physiological genomics - 16 Aug 2006
Grosse Johannes, Tarnow Patrick, Römpler Holger, Schneider Boris, Sedlmeier Reinhard, Huffstadt Ulrike, Korthaus Dirk, Nehls Michael, Wattler Sigrid, Schöneberg Torsten, Biebermann Heike, Augustin Martin
Abstract excerpt
Chemical random mutagenesis techniques with the germ line supermutagen N-ethyl-N-nitrosourea (ENU) have been established to provide comprehensive collections of mouse models, which were then mined and analyzed in phenotype-driven studies. Here, we applied ENU mutagenesis in a high-throughput fashion for a gene-driven identification of new mutations. Selected members of the large superfamily of G protein-coupled...
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