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Article

Molecular cytogenetic characterization of <i>TCF3 (E2A)</i>/19p13.3 rearrangements in B‐cell precursor acute lymphoblastic leukemia

20 Feb 2007

Abstract excerpt

The t(1;19)(q23;p13.3) is one of the most common chromosomal abnormalities in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and usually gives rise to the TCF3-PBX1 fusion gene. Additional rare, and sometimes cytogenetically cryptic, translocations involving the TCF3 gene have also been described. Using a dual color split-signal fluorescence in situ hybridization (FISH) probe, we have investigated the...

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PMID: 17311319
DOI: 10.1002/gcc.20431

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