Article
Molecular investigation of 19p13 in standard and variant translocations: the E12 probe recognizes the 19p13 breakpoint in cases with t(1;19) and acute leukemia other than pre-B immunophenotype.
Leukemia - 1 Jan 1991
Yamada T, Craig J M, Hawkins J M, Janossy G, Secker-Walker L M
Abstract excerpt
The gene E2A has recently been cloned, mapped to 19p13 and shown to be rearranged in cases of pre-B acute lymphoblastic leukemia (ALL) with t(1;19) (q23;p13). Nine cases with a 19p13 breakpoint, four having a phenotype other than pre-B, have been investigated with the E12 probe to the E2A gene. F...
Topics
- Adolescent
- Adult
- Animals
- Blotting, Southern
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 19
- DNA Probes
- Female
- Gene Rearrangement
- Humans
- Male
- Mice
- Phenotype
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Translocation, Genetic