Article
Discerning different in vivo roles of microRNAs by experimental approaches in zebrafish.
Methods in cell biology - 1 Jan 2011
Pase Luke, Lieschke Graham J
Abstract excerpt
MicroRNAs (miRNAs) are small endogenous RNAs of approximately 23 nucleotides that regulate the cellular transcriptome by binding to target mRNAs in a sequence-restricted manner, thereby modulating target transcript translation and turnover. Although the direct repressive trans-acting action of miRNAs is to cause a net reduction in the total amount of protein generated from their target mRNAs, developmental and...
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