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Article

MicroRNA Antagonism of the Picornaviral Life Cycle: Alternative Mechanisms of Interference

18 Mar 2010

Abstract excerpt

In addition to modulating the function and stability of cellular mRNAs, microRNAs can profoundly affect the life cycles of viruses bearing sequence complementary targets, a finding recently exploited to ameliorate toxicities of vaccines and oncolytic viruses. To elucidate the mechanisms underlying microRNA-mediated antiviral activity, we modified the 3' untranslated region (3'UTR) of Coxsackievirus A21 to...

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PMID: 20333250
DOI: 10.1371/journal.ppat.1000820

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