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Article

Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals.

Biological psychiatry - 1 Jan 2007

Salahpour Ali, Medvedev Ivan O, Beaulieu Jean-Martin, Gainetdinov Raul R, Caron Marc G

Abstract excerpt

BACKGROUND: Recent reports have suggested effectiveness of RNA interference (RNAi) for the analysis of gene functions in the brain. This study sought to determine the efficiency of local small interfering RNA (siRNA) injections, comparing this approach with animals generated through classical gene targeting. METHODS: Small interfering RNA against dopamine transporter (DAT) (35 microg/14 days) or tyrosine...

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Source

Identifiers

PMID: 16712807
DOI: 10.1016/j.biopsych.2006.03.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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