Article
No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese.
Human genetics - 1 Aug 2006
Gotoh Norimoto, Yamada Ryo, Hiratani Hitomi, Renault Victor, Kuroiwa Sachiko, Monet Marion, Toyoda Sachiko, Chida Shohei, Mandai Michiko, Otani Atsushi, Yoshimura Nagahisa, Matsuda Fumihiko
Abstract excerpt
Age-related macular degeneration (ARMD) is the leading cause of blindness in the elderly population not only Western but also Asian industrial countries. In Caucasian, a polymorphism of the complement factor H gene (CFH), the C allele of rs1061170 (Y402H), was established as the first strong genetic factor for excursively exudative type of ARMD. In this study, we performed an extensive sequencing of the 22 exons...
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