Article
Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population.
Clinical & experimental ophthalmology - 1 Jul 2008
Gotoh Norimoto, Yamada Ryo, Nakanishi Hideo, Saito Masaaki, Iida Tomohiro, Matsuda Fumihiko, Yoshimura Nagahisa
Abstract excerpt
BACKGROUND: Typical exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are two of the major macular diseases found in Asians. Although genomic studies have shown a contribution by CFH and LOC387715/HTRA1 polymorphisms to the development of these two diseases, the correlation of the clinical phenotypes to these genotypes has not been determined in Asian patients. METHODS:...
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