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Article

Phagocytic entry of Legionella pneumophila into macrophages through phosphatidylinositol 3,4,5-trisphosphate-independent pathway.

Biological & pharmaceutical bulletin - 1 Jan 2012

Harada Toshihiko, Tanikawa Takashi, Iwasaki Yasunori, Yamada Masao, Imai Yasuyuki, Miyake Masaki

Abstract excerpt

Legionella pneumophila, a causative agent of Legionnaire's disease, is an intracellular pathogen. It intervenes in the signal transduction of macrophages by secreting effector molecules through the Icm/Dot type IV secretion system (T4SS). There is a connection between signaling cascades that regulate phagocytosis and the production of reactive oxygen species (ROS). Class I phosphatidylinositol 3-kinase (PI3-K)...

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Identifiers

PMID: 22975496
DOI: 10.1248/bpb.b11-00011

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