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Article

SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase.

Cell reports - 2 Nov 2021

Choi Won Young, Kim Seongok, Aurass Philipp, Huo Wenwen, Creasey Elizabeth A, Edwards Marc, Lowe Martin, Isberg Ralph R

Abstract excerpt

Legionella pneumophila grows intracellularly within a replication vacuole via action of Icm/Dot-secreted proteins. One such protein, SdhA, maintains the integrity of the vacuolar membrane, thereby preventing cytoplasmic degradation of bacteria. We show here that SdhA binds and blocks the action of OCRL (OculoCerebroRenal syndrome of Lowe), an inositol 5-phosphatase pivotal for controlling endosomal dynamics. OCRL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34731604
DOI: 10.1016/j.celrep.2021.109894
PMCID: PMC8669613

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