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Article

Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.

The Journal of biological chemistry - 20 Feb 2009

Brombacher Eva, Urwyler Simon, Ragaz Curdin, Weber Stefan S, Kami Keiichiro, Overduin Michael, Hilbi Hubert

Abstract excerpt

The causative agent of Legionnaires disease, Legionella pneumophila, forms a replicative vacuole in phagocytes by means of the intracellular multiplication/defective organelle trafficking (Icm/Dot) type IV secretion system and translocated effector proteins, some of which subvert host GTP and pho...

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Source

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Identifiers

PMID: 19095644
DOI: 10.1074/jbc.M807505200
PMCID: PMC2643517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19095644-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.PMID 19095644Read ↗

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.Semantic proximity Read ↗

Anchors for Effectors: Subversion of Phosphoinositide Lipids by LegionellaSemantic proximity Read ↗

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.Semantic proximity Read ↗

Legionella pneumophila LidA Affects Nucleotide Binding and Activity of the Host GTPase Rab1Semantic proximity Read ↗

The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.Semantic proximity Read ↗

Legionella pneumophila SidD is a deAMPylase that modifies Rab1.Semantic proximity Read ↗

Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole.Semantic proximity Read ↗

Targeting of the Small GTPase Rab6A′ by the Legionella pneumophila Effector LidASemantic proximity Read ↗

Identification and Structural Characterization of a Legionella Phosphoinositide Phosphatase*Semantic proximity Read ↗

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.Semantic proximity Read ↗

Solution structure of the phosphatidylinositol 3-phosphate binding domain from the <i>Legionella</i> effector SetASemantic proximity Read ↗

Structural basis for substrate recognition by a unique <i>Legionella</i> phosphoinositide phosphataseSemantic proximity Read ↗

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