Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11.

doi:10.1111/j.1365-2249.1991.tb05590.x

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Article

Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11.

Clinical and experimental immunology - 1 Jan 1991

Wong S, Moore S, Orisio S, Millward A, Demaine A G

Abstract excerpt

Type I diabetes is associated with the DQ loci of the MHC and to a lesser extent with the T cell antigen receptor (TcR) beta chain genes. The non-obese diabetic (NOD) mouse is an animal model of human diabetes, in which up to 90% of female mice develop overt insulin-dependent diabetes. Genetic studies in the NOD mouse suggest that there are at least three diabetogenic genes; one that maps to the MHC, another that...

Topics

Adult
Alleles
Autoimmunity
Chromosome Mapping
Chromosomes, Human, Pair 11
DNA Probes
Diabetes Mellitus, Type 1
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DR Antigens

Histocompatibility Testing

Humans

Male

Nucleic Acid Hybridization

Polymorphism, Restriction Fragment Length

Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 1671006
DOI: 10.1111/j.1365-2249.1991.tb05590.x
PMCID: PMC1535466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1671006-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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