Article
The EIF2AK3 gene region and type I diabetes in subjects from South India.
Genes and immunity - 1 Dec 2004
Allotey R A, Mohan V, McDermott M F, Deepa R, Premalatha G, Hassan Z, Cassell P G, North B V, Vaxillaire M, Mein C A, Swan D C, O'Grady E, Ramachandran A, Snehalatha C, Sinnot P J, Hemmatpour S K, Froguel P, Hitman G A
Abstract excerpt
Mutations in the EIF2AK3 gene underlie susceptibility to the Wolcott-Rallison syndrome, which is a monogenic disease associated with insulin-deficient neonatal diabetes. Furthermore, suggestive evidence of linkage between type 1 diabetes (T1DM) and the EIF2KA3 chromosomal region has been reported in Scandinavian families. We have investigated the hypothesis that polymorphic variants in and around the EIF2AK3 gene...
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