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Article

A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b.

Immunology - 1 Apr 2003

Birmingham Daniel J, Chen Wei, Liang Grace, Schmitt Holly C, Gavit Katie, Nagaraja Haikady N

Abstract excerpt

The erythrocyte type one complement receptor (E-CR1) mediates erythrocyte binding of complement-opsonized immune complexes (IC), and helps protect against random deposition of circulating IC. Two linked CR1 polymorphisms occur in binding domains, at I643T and Q981H. In Caucasians, the variant alleles (643T, 981H) are associated with low constitutive E-CR1 expression levels. This study was conducted to determine...

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Identifiers

PMID: 12667215
DOI: 10.1046/j.1365-2567.2003.01579.x
PMCID: PMC1782929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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