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Article

Mitonuclear Compensatory Coevolution.

Trends in genetics : TIG - 1 Jun 2020

Hill Geoffrey E

Abstract excerpt

In bilaterian animals, the mitochondrial genome is small, haploid, does not typically recombine, and is subject to accumulation of deleterious alleles via Muller's ratchet. These basic features of the genomic architecture present a paradox: mutational erosion of these genomes should lead to decline in mitochondrial function over time, yet no such decline is observed. Compensatory coevolution, whereby the nuclear...

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PMID: 32396834
DOI: 10.1016/j.tig.2020.03.002

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