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Article

Nonprogressive transgene-related callosal and hippocampal changes in PDAPP mice.

Neuroreport - 29 May 2006

Valla Jon, Schneider Lonnie E, Gonzalez-Lima Francisco, Reiman Eric M

Abstract excerpt

We have previously shown that homozygous PDAPP mice, a transgenic model of Alzheimer's-like amyloidosis, have abnormal corpus callosi and anterior hippocampi. Now, we investigated the extent to which these morphological abnormalities are correlated with mutant gene dose in a larger, independent, and substantially younger cohort. Homozygous and heterozygous PDAPP mice had significantly smaller callosal commissure...

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Source

Identifiers

PMID: 16708023
DOI: 10.1097/01.wnr.0000220140.91294.15

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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