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Article

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Aug 2005

Spires Tara L, Meyer-Luehmann Melanie, Stern Edward A, McLean Pamela J, Skoch Jesse, Nguyen Paul T, Bacskai Brian J, Hyman Bradley T

Abstract excerpt

Accumulation of amyloid-beta (Abeta) into senile plaques in Alzheimer's disease (AD) is a hallmark neuropathological feature of the disorder, which likely contributes to alterations in neuronal structure and function. Recent work has revealed changes in neurite architecture associated with plaques and functional changes in cortical signaling in amyloid precursor protein (APP) expressing mouse models of AD. Here...

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Source

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Identifiers

PMID: 16079410
DOI: 10.1523/JNEUROSCI.1879-05.2005
PMCID: PMC1820616

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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