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Article

Stabilisation of p53 enhances reovirus-induced apoptosis and virus spread through p53-dependent NF-κB activation.

British journal of cancer - 27 Sept 2011

Pan D, Pan L-Z, Hill R, Marcato P, Shmulevitz M, Vassilev L T, Lee P W K

Abstract excerpt

BACKGROUND: Naturally oncolytic reovirus preferentially kills cancer cells, making it a promising cancer therapeutic. Mutations in tumour suppressor p53 are prevalent in cancers, yet the role of p53 in reovirus oncolysis is relatively unexplored. METHODS: Human cancer cell lines were exposed to Nutlin-3a, reovirus or a combination of the two and cells were processed for reovirus titration, western blot, real-time...

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Identifiers

PMID: 21863032
DOI: 10.1038/bjc.2011.325
PMCID: PMC3185941

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