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Article

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.

The Journal of cell biology - 22 May 2006

Weinert Stefanie, Bergmann Nora, Luo Xiuju, Erdmann Bettina, Gotthardt Michael

Abstract excerpt

Titin, the largest protein known to date, has been linked to sarcomere assembly and function through its elastic adaptor and signaling domains. Titin's M-line region contains a unique kinase domain that has been proposed to regulate sarcomere assembly via its substrate titin cap (T-cap). In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16702235
DOI: 10.1083/jcb.200601014
PMCID: PMC2063865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16702235-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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