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Article

Conditional Expression of Mutant M-line Titins Results in Cardiomyopathy with Altered Sarcomere Structure

1 Feb 2003

Abstract excerpt

Titin is a giant protein responsible for muscle elasticity and provides a scaffold for several sarcomeric proteins, including the novel titin-binding protein MURF-1, which binds near the titin M-line region. Another unique feature of titin is the presence of a serine/threonine kinase-like domain at the edge of the M-line region of the sarcomere, for which no physiological catalytic function has yet been shown. To...

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PMID: 12464612
DOI: 10.1074/jbc.m211723200

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Conditional Expression of Mutant M-line Titins Results in Cardiomyopathy with Altered Sarcomere StructurePMID 12464612Read ↗

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