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Article

Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association - 1 Dec 2004

Sivenius K, Niskanen L, Voutilainen-Kaunisto R, Laakso M, Uusitupa M

Abstract excerpt

AIMS: The gene encoding the human aldose reductase, the first and rate-limiting enzyme of the polyol pathway of glucose metabolism, is a promising candidate gene which may contribute to diabetic microvascular complications. We investigated the association of two previously reported DNA sequence variants of this gene, the C-106T polymorphism and the (CA)(n) dinucleotide repeat marker, with the risk of albuminuria...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15569136
DOI: 10.1111/j.1464-5491.2004.01345.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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