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Article

Direct inference of SNP heterozygosity rates and resolution of LOH detection.

PLoS computational biology - 1 Nov 2007

Li Xiaohong, Self Steven G, Galipeau Patricia C, Paulson Thomas G, Reid Brian J

Abstract excerpt

Single nucleotide polymorphisms (SNPs) have been increasingly utilized to investigate somatic genetic abnormalities in premalignancy and cancer. LOH is a common alteration observed during cancer development, and SNP assays have been used to identify LOH at specific chromosomal regions. The design of such studies requires consideration of the resolution for detecting LOH throughout the genome and identification of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18052545
DOI: 10.1371/journal.pcbi.0030244
PMCID: PMC2098867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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