Article
Absence of beta-catenin alteration in hepatic tumors induced by p-nitroanisole in Crj:BDF1 mice.
Toxicologic pathology - 1 Jan 2006
Kushida Masahiko, Aiso Sigetoshi, Morimura Keiichirou, Wei Min, Wanibuchi Hideki, Nagano Kasuke, Fukushima Shoji
Abstract excerpt
In the present study, beta-catenin localization in hepatocellular neoplasms and hepatoblastomas, induced by oral administration of p-Nitroanisole (pNA) in Crj:BDF1 for 2 years, was evaluated by immunohistochemistry along with genetic alterations in exon 2 of beta-catenin by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) approach. Genomic DNA was isolated from paraffin sections of...
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