Article
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.
Cancer research - 1 Apr 2002
Harada Naomoto, Miyoshi Hiroyuki, Murai Naomi, Oshima Hiroko, Tamai Yoshitaka, Oshima Masanobu, Taketo Makoto M
Abstract excerpt
Mutations in the glycogen synthase kinase 3beta (GSK3beta) phosphorylation sites of the beta-catenin gene exon 3 are found in 20-30% of human primary hepatocellular carcinoma (HCC), whereas mutations in the APC or AXIN genes are found in other HCC populations. These data strongly suggest that the Wnt signaling pathway is involved in hepatocarcinogenesis. To determine the role of beta-catenin in intestinal...
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