Article
Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing.
Molecular cell - 1 Jul 2002
Tasic Bosiljka, Nabholz Christoph E, Baldwin Kristin K, Kim Youngwook, Rueckert Erroll H, Ribich Scott A, Cramer Paula, Wu Qiang, Axel Richard, Maniatis Tom
Abstract excerpt
A family of mammalian protocadherin (Pcdh) proteins is encoded by three closely linked gene clusters (alpha, beta, and gamma). Multiple alpha and gamma Pcdh mRNAs are expressed in distinct patterns in the nervous system and are generated by alternative pre-mRNA splicing between different "variable" exons and three "constant" exons within each cluster. We show that each Pcdh variable exon is preceded by a promoter...
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