Article
Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.
Genome research - 1 Mar 2001
Wu Q, Zhang T, Cheng J F, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan J P, Zhang M Q, Myers R M, Maniatis T
Abstract excerpt
The genomic organization of the human protocadherin alpha, beta, and gamma gene clusters (designated Pcdh alpha [gene symbol PCDHA], Pcdh beta [PCDHB], and Pcdh gamma [PCDHG]) is remarkably similar to that of immunoglobulin and T-cell receptor genes. The extracellular and transmembrane domains of each protocadherin protein are encoded by an unusually large "variable" region exon, while the intracellular domains...
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