Article
Phenotypes associated with psychiatric disorders are sex-specific in a mutant mouse line.
Brain research - 1 Dec 2016
Nakajima Mitsunari, Watanabe Takashi, Aoki Rui, Shimizu Risei, Okuyama Satoshi, Furukawa Yoshiko
Abstract excerpt
Wnt1-Cre- and Wnt1-GAL4 double transgenic (dTg) mice are used to study neural crest cell lineages by utilizing either the Cre/loxP or the GAL4/UAS system. We have previously shown that these mice exhibit behavioral abnormalities that resemble certain behaviors of psychiatric disorders and histologic alterations in the cholinergic and glutamatergic systems in the brain. The objective of the current study was to...
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