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Article

Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study.

Arthritis research & therapy - 1 Jan 2006

Gilbert Sophie J, Blain Emma J, Jones Pamela, Duance Victor C, Mason Deborah J

Abstract excerpt

We previously established a role for the second messenger ceramide in protein kinase R (PKR)-mediated articular cartilage degradation. Ceramide is known to play a dual role in collagen gene regulation, with the effect of ceramide on collagen promoter activity being dependent on its concentration. Treatment of cells with low doses of sphingomyelinase produces small increases in endogenous ceramide. We investigated...

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Source

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Identifiers

PMID: 16696862
DOI: 10.1186/ar1961
PMCID: PMC1779424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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