Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner.

The EMBO journal - 3 May 2006

Moorthy Anu K, Savinova Olga V, Ho Jessica Q, Wang Vivien Ya-Fan, Vu Don, Ghosh Gourisankar

Abstract excerpt

The NF-kappaB p50 is the N-terminal processed product of the precursor, p105. It has been suggested that p50 is generated not from full-length p105 but cotranslationally from incompletely synthesized molecules by the proteasome. We show that the 20S proteasome endoproteolytically cleaves the fully synthesized p105 and selectively degrades the C-terminus of p105, leading to p50 generation in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ankyrin Repeat
Share to Glycine
Share to NF-kappa B p50 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteasome Endopeptidase Complex

Share to Protein Biosynthesis

Share to Protein Processing, Post-Translational

Share to Protein Structure, Tertiary

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 16619030
DOI: 10.1038/sj.emboj.7601081
PMCID: PMC1456938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner.PMID 16619030Read ↗

Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain.Semantic proximity Read ↗

Characterization of ES cells deficient for the p105 precursor (NF-kappa B1): role of p50 NLS.Semantic proximity Read ↗

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.Semantic proximity Read ↗

Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters.Semantic proximity Read ↗

NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic InflammationSemantic proximity Read ↗

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation.Semantic proximity Read ↗

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.Semantic proximity Read ↗

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100.Semantic proximity Read ↗

Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.Semantic proximity Read ↗

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.Semantic proximity Read ↗

Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.Semantic proximity Read ↗

Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.