Article
Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction.
Schizophrenia bulletin - 1 Jul 2006
Saperstein Alice M, Fuller Rebecca L, Avila Matthew T, Adami Helene, McMahon Robert P, Thaker Gunvant K, Gold James M
Abstract excerpt
Research suggests that first-degree relatives and individuals with schizophrenia spectrum personality disorders (SSPD) may represent nonpenetrant carriers of the genetic diathesis for schizophrenia. This study examined visuospatial working memory (SWM) as a cognitive endophenotype of schizophrenia by expanding the concept of risk for pathophysiological dysfunction beyond overt psychosis. Risk was thus defined by...
Topics
- Adult
- Brain
- Cognition Disorders
- Demography
- Diagnosis, Computer-Assisted
- Diagnostic and Statistical Manual of Mental Disorders
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Memory Disorders
- Neuropsychological Tests
- Phenotype