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Article

Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction.

Schizophrenia bulletin - 1 Jul 2006

Saperstein Alice M, Fuller Rebecca L, Avila Matthew T, Adami Helene, McMahon Robert P, Thaker Gunvant K, Gold James M

Abstract excerpt

Research suggests that first-degree relatives and individuals with schizophrenia spectrum personality disorders (SSPD) may represent nonpenetrant carriers of the genetic diathesis for schizophrenia. This study examined visuospatial working memory (SWM) as a cognitive endophenotype of schizophrenia by expanding the concept of risk for pathophysiological dysfunction beyond overt psychosis. Risk was thus defined by...

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Identifiers

PMID: 16687386
DOI: 10.1093/schbul/sbj072
PMCID: PMC2632247

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