Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data.

doi:10.1093/schbul/sbaf050

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Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data.

Schizophrenia bulletin - 16 Jan 2026

Kravariti Eugenia, Fragkaki Anna-Maria, Georgiades Anna, Cardno Alastair G, Kane Fergus, Kalidindi Sridevi, Schulze Katja K, McDonald Colm, Picchioni Marco M, Hall Mei-Hua, Watson Cameron J, Glenthøj Birte Y, Ebdrup Bjørn H, Fagerlund Birgitte, Lemvigh Cecilie K, Van Haren Neeltje E M, Kahn Rene, Murray Robin M, Rijsdijk Fruhling, Toulopoulou Timothea

Abstract excerpt

BACKGROUND: Psychiatric research is increasingly embracing a paradigm shift from categorical diagnoses to neurobiologically meaningful dimensions that cross current diagnostic boundaries. This transposition calls for redefining endophenotypes to accommodate transdiagnostic vulnerabilities. We sought to identify shared and disorder-specific neurocognitive endophenotypes for schizophrenia, bipolar I disorder (BD-I)...

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PMID: 40341418
DOI: 10.1093/schbul/sbaf050
PMCID: PMC12809861

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