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Article

Integrative Genomic Analysis Predicts Causative Cis-Regulatory Mechanisms of the Breast Cancer-Associated Genetic Variant rs4415084.

Cancer research - 1 Apr 2018

Zhang Yi, Manjunath Mohith, Zhang Shilu, Chasman Deborah, Roy Sushmita, Song Jun S

Abstract excerpt

Previous genome-wide association studies (GWAS) have identified several common genetic variants that may significantly modulate cancer susceptibility. However, the precise molecular mechanisms behind these associations remain largely unknown; it is often not clear whether discovered variants are themselves functional or merely genetically linked to other functional variants. Here, we provide an integrated method...

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Share to Chromosomes, Human, Pair 5
Share to GATA3 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to High-Throughput Nucleotide Sequencing

Share to Mitochondrial Proteins

Share to Regulatory Sequences, Nucleic Acid

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Share to RNA, Long Noncoding

Source

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Identifiers

PMID: 29351903
DOI: 10.1158/0008-5472.CAN-17-3486
PMCID: PMC5882544

Genes

MRPS30
GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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