Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of Pim-1 function in mutant mice.

Leukemia - 1 Aug 1993

Domen J, van der Lugt N M, Laird P W, Saris C J, Berns A

Abstract excerpt

The Pim-1 gene has frequently been found activated by proviral insertion in haematopoietic tumors in mice. The fact that overexpression of Pim-1 can contribute to lymphomagenesis was formally proven by overexpressing a Pim-1 transgene in lymphoid cells. The transgene induces a low incidence of T cell lymphomas and an increased susceptibility to chemically (ENU) and virally (MoMuLV) induced lymphomas. The mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA, Messenger
Share to Alleles
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Division

Share to Cells, Cultured

Share to Genotype

Share to Molecular Sequence Data

Source

Identifiers

PMID: 8361211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Pim-1 function in mutant mice.PMID 8361211Read ↗

Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and CarcinogensSemantic proximity Read ↗

A review on PIM kinases in tumorsSemantic proximity Read ↗

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterusSemantic proximity Read ↗

The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomasSemantic proximity Read ↗

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.Semantic proximity Read ↗

Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice.Semantic proximity Read ↗

The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action.Semantic proximity Read ↗

The role of PIM1/PIM2 kinases in tumors of the male reproductive systemSemantic proximity Read ↗

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.Semantic proximity Read ↗

Why Target PIM1 for Cancer Diagnosis and Treatment?Semantic proximity Read ↗

Mice Bearing the Eµ- <i>myc</i> and Eµ- <i>pim</i> -l Transgenes Develop Pre-B-Cell Leukemia PrenatallySemantic proximity Read ↗

Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell LymphomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.