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Article

Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America - 16 May 2006

Arora Meenakshi, Chen Li, Paglia Melissa, Gallagher Iain, Allen Judith E, Vyas Yatin M, Ray Anuradha, Ray Prabir

Abstract excerpt

Statins, best known for their lipid-lowering actions, also possess immunomodulatory properties. Recent studies have shown a Th2-biasing effect of statins, although the underlying mechanism has not been identified. In this study, we investigated whether simvastatin can exercise a Th2-promoting effect through modulation of function of dendritic cells (DCs) without direct interaction with CD4+ T cells. Exposure of...

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Identifiers

PMID: 16682645
DOI: 10.1073/pnas.0508492103
PMCID: PMC1472521

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STAT6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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