Article
Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN.
Molecular immunology - 1 Apr 2010
van Stijn Caroline M W, Meyer Sandra, van den Broek Marloes, Bruijns Sven C M, van Kooyk Yvette, Geyer Rudolf, van Die Irma
Abstract excerpt
In schistosomiasis, a major human parasitic disease caused by helminths, different life-stages of the parasite contribute to the developing host immune response. To increase our understanding of the mechanisms that play a role in shaping the host immune responses, we have investigated the effects of schistosome glycoconjugates on the phenotype of dendritic cells (DCs), which form a crucial link between the innate...
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