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Article

Loss of Siglec expression on T lymphocytes during human evolution

8 May 2006

Abstract excerpt

We report here that human T cells give much stronger proliferative responses to specific activation via the T cell receptor (TCR) than those from chimpanzees, our closest evolutionary relatives. Nonspecific activation using phytohemagglutinin was robust in chimpanzee T cells, indicating that the much lower response to TCR simulation is not due to any intrinsic inability to respond to an activating stimulus....

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PMID: 16682635
DOI: 10.1073/pnas.0510484103

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