Article
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
The Journal of biological chemistry - 1 Jul 2011
Mitra Nivedita, Banda Kalyan, Altheide Tasha K, Schaffer Lana, Johnson-Pais Teresa L, Beuten Joke, Leach Robin J, Angata Takashi, Varki Nissi, Varki Ajit
Abstract excerpt
The primate SIGLEC12 gene encodes one of the CD33-related Siglec family of signaling molecules in immune cells. We had previously reported that this gene harbors a human-specific missense mutation of the codon for an Arg residue required for sialic acid recognition. Here we show that this R122C mutation of the Siglec-XII protein is fixed in the human population, i.e. it occurred prior to the origin of modern...
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