Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Focal adhesions are hotspots for keratin filament precursor formation.

The Journal of cell biology - 8 May 2006

Windoffer Reinhard, Kölsch Anne, Wöll Stefan, Leube Rudolf E

Abstract excerpt

Recent studies showed that keratin filament (KF) formation originates primarily from sites close to the actin-rich cell cortex. To further characterize these sites, we performed multicolor fluorescence imaging of living cells and found drastically increased KF assembly in regions of elevated actin turnover, i.e., in lamellipodia. Abundant KF precursors (KFPs) appeared within these areas at the distal tips of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidermolysis Bullosa Simplex
Share to Keratin-14
Share to Marine Toxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metalloproteins

Share to Paxillin

Share to Stress Fibers

Share to Thiazolidines

Source

Open in PubMed Open full text

Identifiers

PMID: 16682525
DOI: 10.1083/jcb.200511124
PMCID: PMC2063835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Focal adhesions are hotspots for keratin filament precursor formation.PMID 16682525Read ↗

Actin‐dependent dynamics of keratin filament precursorsSemantic proximity Read ↗

Multiple roles for keratin intermediate filaments in the regulation of epithelial barrier function and apico-basal polaritySemantic proximity Read ↗

Keratins: a structural scaffold with emerging functions.Semantic proximity Read ↗

The role of integrin-linked kinase in the molecular architecture of focal adhesionsSemantic proximity Read ↗

KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanismSemantic proximity Read ↗

A novel role for integrin-linked kinase in epithelial sheet morphogenesis.Semantic proximity Read ↗

Epithelial Intermediate Filaments: Guardians against Microbial Infection?Semantic proximity Read ↗

Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdownSemantic proximity Read ↗

Talin and vinculin combine their activities to trigger actin assembly.Semantic proximity Read ↗

The expanding significance of keratin intermediate filaments in normal and diseased epitheliaSemantic proximity Read ↗

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions.Semantic proximity Read ↗

Superresolution architecture of pluripotency guarding adhesionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.