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mtDNA mutations and common neurodegenerative disorders.

Trends in genetics : TIG - 1 Nov 2005

Howell Neil, Elson Joanna L, Chinnery Patrick F, Turnbull Douglass M

Abstract excerpt

The incidence and prevalence of Alzheimer's disease (AD) and Parkinson's disease (PD) are increasing as the population ages. Both disorders have been associated with oxidative stress and mitochondrial dysfunction, and it has been proposed that mutations in the mitochondrial genome have a key role in neurodegeneration in AD and PD patients. Two recent publications propose that heteroplasmic mtDNA mutations are...

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PMID: 16154228
DOI: 10.1016/j.tig.2005.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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