Article
Molecular characterization of complete and incomplete immunoglobulin heavy chain gene rearrangements in hairy cell leukemia.
Clinical lymphoma & myeloma - 1 Nov 2007
Martín-Jiménez Patricia, García-Sanz Ramón, González David, Balanzategui Ana, Pérez José J, Caballero M Dolores, Sarasquete M Eugenia, Galende Josefina, Orfao Alberto, López-Berges M Consuelo, San Miguel Jesús F, González Marcos
Abstract excerpt
PURPOSE: We analyzed patients with hairy cell leukemia (HCL) to achieve a better understanding of the differentiation stage reached by HCL cells and to define the key role of the diversification of cell surface makers, especially CD25 expression. PATIENTS AND METHODS: We analyzed 38 previously untreated patients with HCL to characterize their complete (VDJ(H)) and incomplete (DJ(H)) immunoglobulin (Ig) heavy...
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